0419 Characterization of Sleep Quality in Patients with Idiopathic Hypersomnia using Cardiopulmonary Coupling

Abstract Introduction Idiopathic Hypersomnia (IH) is characterized clinically by excessive daytime sleepiness, prolonged or unrefreshing sleep, and sleep inertia. The ICSD-3 classifies IH as having expected proportions of NREM REM normal latency relatively high efficiency. However, there limited granular data on quality in these patients whether this disease state comprises with a homogenous spectrum quality. aim study to describe the using ECG derived spectrogram. Methods This single center cross sectional where we identified 37 consecutive extended studies for 10 more hours total time (TST). spectrogram an plethysmography based system which evaluates stability principle autonomic respiratory oscillations (cardiopulmonary coupling). High frequency coupling (HFC) associated stable sleep. Sleep index (SQI) strongly weighted HFC. We priori decided divide population into 2 groups SQI ≥55 (there published supportive threshold adults) compare them T-test. Multivariable logistic regression was performed adjusting age, sex, TST apnea-hypopnea index-3% (AHI) <10 assess predictors low discovered. Results mean age cohort 35.4 years (SD 16.2), 30 (81%) were females. Mean 660 minutes 16.2) efficiency 86% 9) 59% 19.1). AHI 10.4 12.3). Stratifying gave us distinct 71.5 9.3) group SQI≥55 38.5 11.6) <55 [p-value <0.001]. In analysis, not predicted <10, gender time. Conclusion Based our cohort, at least two clusters IH. anticipate that findings here will lead further insights physiology phenotypes. Support (If Any)